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KMID : 0043320080310081066
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Archives of Pharmacal Research
2008 Volume.31 No. 8 p.1066 ~ p.1072
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Chiral Separation of Fluvastatin Enantiomers by Capillary Electrophoresis
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Trung Tran Quoc
Dung Phan Thanh
Hoan Nguyen Ngoc
Kim Dae-Joong
Lee Joo-Hyun
Kim Kyeong-Ho
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Abstract
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An analytical CE method was developed for the enantiomeric purity determination of fluvastatin enantiomers. Fluvastatin enantiomers were separated on an uncoated fused silica with 100 mM-borate solution containing 30 mg/mL of (2-hydroxypropyl)--cyclodextrin (HP--CD) as running buffer and fenoprofen as an internal standard. The linearity was observed within a concentration range () for both fluvastatin enantiomers. The repeatability expressed as coefficient of variation (CV) of the method were 0.96 and 0.92% for (+)-3R, 5S and (-)-3S, 5R-fluvastatin, respectively. The limit of detection and quantification for both fluvastatin enantiomers were and , respectively.
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KEYWORD
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Fluvastatin, Fenoprofen, CE, Chiral separation, Enantiomer
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